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Bids_Invited_for_the_transfer_of_Technologies

Sr._No.

Brief_about_Technology

Application_Area_and_Related_Industries

A_novel_anti-cancer_combination_therapy

The_present_invention_relates_to_the_identification_of_new_cellular_target_of_micro-RNA-_mir-24-2,_i.e._BCL-2,_an_anti-apoptotic_gene,_and_methods_of_its_use_to_increase_apoptosis_(cell_death)_of_cancer_cells_in_presence_of_200-400_fold_reduced_dose_of_anti-cancer_drugs._The_approach_has_the_potential_to_reduce_toxicity_to_non-cancerous_cells_considerably_and_allow_improved_quality_of_life_during_therapeutic_intervention._The_invention_described_here_provides_a_new_anti-cancer_combination_therapy_that_utilizes_over-expression_of_mir-24-2_to_potentiate_the_apoptotic_pathway_by_down-regulating_the_expression_of_BCL-2,_H2AFX,_MDM2_and_P21_genes._It_has_been_demonstrated_herein_that_treatment_of_breast_cancer_cells,_MCF7,_with_anti-cancer_drugs_like,_Cisplatin_along_with_over-expression_of_micro-RNA,_mir-24-2_has_additive_effect_in_inducing_apoptotic_cell_death._A_patent_application_for_this_IPR_protection_has_been_filed_in_2011,_displayed_on_Pg_No_635_in_"Official_Journal_of_The_Patent_Office;_Issue_No_02/2013"_(Click_Here_to_Download)

Interested_parties_who_want_to_bid_for_the_technology_may_submit_their_bid_in_the_office_of_chairperson,_Intellectual_Property_Management_Cell,_Room_No._117,_Administration_Block,_Jawaharlal_Nehru_University,_New_Delhi-110067,_so_as_to_reach_this_office_on_or_before_30th_November,_2014._For_any_further_clarification_and_seeking_appointment_the_interested_parties_can_contact:_Prof_R_N_K_Bamezai,_School_of_Life_Sciences,_Jawaharlal_Nehru_University,_New_Delhi-110067_by_email:_bamezai@hotmail.com_or_phone_+91_11_26704518.

Click_Here_to_Download

All_Pharmaceutical_Industries

Nutritionally_Improved_Rice_fortified_with_High_Lysine

In_the_major_cereal_grains_(wheat,_rice,_maize_etc.),_which_represent_the_largest_source_of_food_and_feed_worldwide,_lysine_is_the_most_limiting_essential_amino_acid_and_it_is_therefore_considered_as_a_nutritionally_significant_amino_acid._Rice_is_the_most_important_staple_food_for_a_large_part_of_world's_population,_especially_in_East_and_South_Asia,_the_Middle_East,_Latin_America,_and_the_West_Indies._Rice_grains_are_deficient_in_certain_essential_amino_acids,_especially_lysine._Lysine_plays_a_major_role_in_calcium_absorption;_building_muscle_protein;_recovering_from_surgery_or_sport_injuries;_and_production_of_hormones,_enzymes_and_antibodies._It_also_helps_to_prevent_herpes_and_osteoporosis._Lysine_deficiency_results_in_appetite_loss,_poor_growth,_fatigue,_anemia_etc._We_need_51_milligrams_of_lysine,_also_called_L-lysine,_for_each_gram_of_protein_we_eat._Therefore,_the_average_woman_should_get_approximately_2.3_grams_of_lysine_per_day,_and_the_average_man_should_get_about_2.8_grams._Lysine_promotes_proper_organ_development_and_muscle_growth._It_helps_in_production_of_carnitine,_a_nutrient_responsible_for_converting_fatty_acids_into_energy_and_helping_our_body_to_lower_the_cholesterol._Therefore,_efforts_are_being_made_to_improve_the_nutritional_quality_of_rice_with_high_lysine_content._In_light_of_these_implications,_we_have_done_metabolic_engineering_in_rice_to_increase_its_lysine_contents._It_is_also_estimated_that_increasing_lysine_content_could_increase_the_gross_value_of_rice_in_world_feed_market._A_patent_application_for_this_IPR_protection_has_been_filed.

Interested_parties_who_want_to_bid_for_the_technology_may_submit_their_bid_in_the_office_of_chairperson,_Intellectual_Property_Management_Cell,_Room_No._117,_Administration_Block,_Jawaharlal_Nehru_University,_New_Delhi-110067,_so_as_to_reach_this_office on_or_before_31st_October,_2014. For_any_further_clarification_and_seeking_appointment_the_interested_parties_can_contact: Professor_Ashwani_Pareek,_School_of_Life_Sciences,_Jawaharlal_Nehru_University,_New_Delhi-110067 by_email: ashwanipareek@gmail.com or_phone_+91_11_26704504.

Plant_Biotechnology,_Pharmaceutical_and_Seed_Industries

A_non-GM_based_improved_rice_with_higher_yields_capable_of_growing_under_high_temperature,_mild_drought_and_poor_quality_water_(salinity)

The_present_invention_provides_an_improved_and_novel_rice_type_which_is_having_high_yield_and_is_also_tolerant_to_multiple_abiotic_stresses_(high_temperature,_drought_and_salinity_or_poor_quality_water)._This_novel_rice_type_has_the_capacity_to_produce_higher_grains_under_control_as_well_as_under_various_abiotic_stress_conditions._This_is_a_dwarf_rice_and_hence,_easy_to_handle_during_farming._This_rice_plant_shows_early_maturity_and_short_life_span_than_the_wild_type_(WT,_cv_IR64)._Grain_size_of_this_rice_with_or_without_husk_or_after_boiling_is_bigger_than_the_WT._Grain_weight_of_the_developed_rice_is_also_higher_than_that_of_WT._This_rice_can_be_highly_suitable_for_its_further_use_in_industries_or_in_farming._A_patent_application_for_this_IPR_protection_has_been_filed.

Figure:_Phenotype_of_WT_and_investigated_rice_plants_along_with_their_panicle_morphology.

Interested_parties_who_want_to_bid_for_the_technology_may_submit_their_bid_in_the_office_of_Chairperson,_Intellectual_Property_Management_Cell,_Room_No._117,_Administration_Block,_Jawaharlal_Nehru_University,_New_Delhi-110067,_so_as_to_reach_this_office on_or_before_31st_October_2014. For_any_further_clarification_and_seeking_appointment_the_interested_parties_can_contact: Professor_Ashwani_Pareek,_School_of_Life_Sciences,_Jawaharlal_Nehru_University,_New_Delhi-110067 by_email: ashwanipareek@gmail.com or_Phone_26704504.

Plant_Biotechnology,_Pharmaceutical_and_Seed_Industries

Stable_integration_of_a_xenobiotic_receptor_promoter-reporter_DNA_construct_into_human_liver_cell_line_for_evaluating_the_drugs_by_high_throughput_screening

The_Pregnane_&_Xenobiotic_Receptor_(PXR;_NR1I2),_a_member_of_the_nuclear_receptor_super-family,_is_a_well-known_xenobiotic_sensing_receptor._The_highly_promiscuous_nature_of_PXR_allows_it_to_interact_with_a_wide_range_of_structurally_diverse_chemicals._Ligand-activated_PXR_up-regulates_the_expression_of_drug-metabolizing_enzymes_and_drug_transporters_to_protect_the_cell_from_chemical_insults._However,_the_physiological_importance_of_PXR_extends_beyond_xenobiotic_protection._Most_importantly,_the_regulation_of_drug-metabolizing_enzymes_by_PXR_may_result_in_clinical_drug–drug_interactions,_in_which_one_drug_accelerates_the_metabolism_of_a_second_medication_and_may_change_or_cause_adverse_results._This_not_only_reduces_the_therapeutic_efficacy_of_many_drugs_on_combination_therapy_but_may_also_cause_life-threatening_situations._Therefore,_the_complete_evaluation_and_safety_assessment_of_any_drug_(clinical_or_herbal)_which_is_to_be_administered_is_indispensable. _Although_there_are_various_methods,_which_are_available_to_assess_the_pharmacological_properties_by_drug_screening,_but_due_to_their_high_cost,_lengthy_experimental_duration_offers_only_limited_use.In_this_context,_a_cell_based_screening_approach_for_evaluating_the_therapeutic_value_and_safety_assessment_of_clinical_or_herbal_drugs,_xenobiotics_and_endobiotics_are_capable_of_being_addressed_at_two_main_levels_by_engaging_(i)_PXR_protein_based_or_(ii)_PXR-promoter_based_transcription_assays:

Cell_based_screening_protocol_for_'Level_1'_is_already_available_(22,_EPO-_WO2004016759,_USPTO-_20040077080)_but_cell_based_screening_protocol_for_'Level_2'_is_now_possible_here._The_present_claim_relates_to_achievement_of_'Level_2'_screening_for_drugs,_xenobiotics_and_endobiotics._This_screening_is_achieved_with_the_use_of_PXR-promoter-reporter_construct_that_we_have_developed_and_stably_integrated_into_a_human_liver_cell_line._Additional_advantages_of_this_stable_PXR-promoter-reporter_cell_line_would_be_in_its_ability_to_predict_potential_drug-drug_interactions,_to_identify_PXR_regulatory_proteins,_and_also_to_evaluate_the_modulatory_effects_of_an_experimental_molecule_on_PXR_promoter_activity.

In_conclusion,_the_present_invention_relates_to_a_stably_integrated_PXR_promoter-reporter_construct-cell_line_comprising_PXR_promoter_of_-1096_to_+43_region_which_is_capable_of_assessing_drug's_capability_to_bind_and_induce_PXR-promoter_on_its_administration,_and_hence,_is_capable_of_indirectly_influencing_the_protein_level_of_the_PXR-promoter_on_its_administration_so_as_to_avoid_failure_of_combination_therapy._In_one_embodiment,_it_relates_to_a_method_of_preparation_of_stably_integrated_PXR_promoter-reporter_construct-cell_line._In_another_embodiment,_it_relates_to_a_PXR_promoter_and_to_a_PXR-promoter-reporter_construct.

Interested_parties_who_want_to_bid_for_the_technology_may_submit_their_bid_in_the_office_of _Chairperson,_Intellectual_Property_Management_cell,_Room_No.117,_Administration_Block,_Jawaharlal_Nehru_University,_New_Delhi-110067,_so_as_to_reach_this_office on_or_before_20th_August,_2012._For_any_further_clarification_and_seeking_appointment_the_interested_parties_can_contact: Dr._Rakesh_K._Tyagi,_Special_Centre_for_Molecular_Medicine,_Jawaharlal_Nehru_University,_New_Delhi_-110067 by e.mail: rktyagi@yahoo.com

Include_Pharmaceutical_companies_and_industries_industries_involved_in_toxicological_evaluation_of_xenobiotics_(clinical_drugs,_herbal_drugs_pesticides_etc)_and_endobiotic_metabolites.

HYBRID-TYPE_HISTIDINE_KINASE_GENE_ISOLATED_FROM_INDICA_RICE_IR64

The_present_invention_provides_a_hybrid-type_histidine_kinase_gene_isolated_from_indica_rice_IR64,_and_being_capable_of_osmosensing_and_inducible_by_multiple_stresses,_and_hence,_being_capable_of_improving_the_multiple_stress_tolerance_of_the_crop_plants_even_in_subsequent_generations_so_as_to_make_the_plants_capable_of_coping-_up_with_the_more_than_one_environmental_abiotic_stress_conditions,_and_therefore,_increasing_the_economic_value_of_the_crop_plants_while_maintaining_the_yield_thereof._The_present_invention_also_provides_a_method_of_isolation_of_hybrid-type_histidine_kinase_gene_from_indica_rice_IR64,_and_its_functional_characteristics_and_its_sequence_listing_and_cloning,_at_least,_with_yeast_expression_vector_and_the_plant_expression_vector,_and_clones_produced_thereby,_and_method_of_improving_multiple_stress_tolerance_of_crop_plant_and_crop_plants_having_improved_multiple_stress_tolerance._Patent_application_(Indian_as_well_as_PCT)_has_been_filed.

Interested_parties_who_want_to_bid_for_the_technology_may_submit_their_bid_in_the_office_of _Chairperson,_Intellectual_Property_Management_cell,_Room_No.117,_Administration_Block,_Jawaharlal_Nehru_University,_New_Delhi-110067,_so_as_to_reach_this_office_on_or_before 15^th January_2011. For_any_further_clarification_and_seeking_appointment_the_interested_parties_can_contact: Ashwani_Pareek,_School_of_Life_Sciences_Jawaharlal_Nehru_University,_New_Delhi_-110067 by_email: ashwanipareek@gmail.com

All _Pharmaceutical_Industries

METHOD_FOR_ENHANCING_REGENERATION_FREQUENCY_OF_BRASSICA_SPECIES

The_present_invention_relates_to_a_method_for_enhancing_the_regeneration_frequency_of_varieties_of Brassica_sps.,_wherein_the_method_is_characterized_by_comprising_treatment_of_hypocotyls_explants_segments_of Brassica_sps._with_a_medium_comprising_Benzyl_Amino_Purine_and_Napthalene_Acetic_Acid_[B1N1_medium],_wherein_the_treatment_results_in_fast_callus_initiation,_root_hairs_initiation,_appearance_of_green_spots_in_the_callus_so_formed,_and_granulation_of_callus_so_formed,_and_appearance_of_anthocyanin_pigmentation_in_few_species_of_Brassica._Patent_application_(Indian_as_well_as_PCT)_has_been_filed.

Interested_parties_who_want_to_bid_for_the_technology_may_submit_their_bid_in_the_office_of _Chairperson,_Intellectual_Property_Management_cell,_Room_No.117,_Administration_Block,_Jawaharlal_Nehru_University,_New_Delhi-110067,_so_as_to_reach_this_office_on_or_before 5^th January_2011. For_any_further_clarification_and_seeking_appointment_the_interested_parties_can_contact: Ashwani_Pareek,_School_of_Life_Sciences_Jawaharlal_Nehru_University,_New_Delhi_-110067 by_email: ashwanipareek@gmail.com

All _Pharmaceutical_Industries

CURCUMIN_NANO_FORM_FOR_MALARIA_THERAPY

Curcumin,_the_yellow_pigment_present_in_the_Indian_spice_turmeric,_has_great_therapeutic_potential._But_it_has_not_yet_become_possible_to_use_it_as_a_drug_due_to_it’s_poor_bioavailability._We_have_developed_the_technology_to_prepare_the_nano_form_of_pure_curcumin_which_when_administered_orally_to_mice_and_rats_shows_about_10_times_increased_bioavailability_in_comparison_to_normal_curcumin_and_cures Plasmodium_yoelii infection_in_mice._The_nano_form_of_curcumin_does_not_show_any_toxicity_in_mice_and_rats_when_fed_for_21_days_at_1gm/Kg_body_weight._Feeding_1_gm_of_curcumin_in_nano_form_to_healthy_human_volunteers_for_15_days_did_not_show_any_adverse_effect._It_retains_it’s_bioactivity_in_the_powder_form_for_1_year_when_kept_at_room_temperature._Patent_application_(Indian_as_well_as_PCT)_has_been_filed_to_protect_our_IPR._Interested_parties_who_want_to_bid_for_the_technology_may_submit_their_bid_in_the_office_of_Chairperson,_Intellectual_Property_Management_Cell,_Room_no_117,_Administration_Block,_JNU,_NewDelhi-110067._Tel:_011-26704093,_Fax:_+91_1126742040_E-mail: ipmcell@mail.jnu.ac.in by_5_pm_of 30^thJuly,_2010. For_any_further_clarification_and_seeking_appointment_the_interested_parties_can_contact: Prof._Santosh_K_Kar,_School_of_Biotechnology,_Jawaharlal_Nehru_University,_New_Delhi_by_email: santoshkariis@rediffmail.com

All _Pharmaceutical_Industries

The_technology_for_very_long_life_incandescent_Bulb_and_Fluorescent_tube

has_been_developed_for_normal_lighting_purposes_that_can_be_further_modified_for_several_applications._The_invention_is_of_great_commercial_application_and_can_be_exploited_very_well_in_next_10-20_years._The_Interested_parties_are_hereby_requested_to_submit_a_letter_of_intent_to_this_effect_and_invited_to_discuss_the_invention,_following_signing_a_non-disclosure_agreement._The_license_agreement_will_include,_amongst_others,_provisions_for_upfront_payments,_royalty_percentages_and_infringement_issues._Intent_for_the_said_technology_may_be_submitted_in_sealed_covers_to_The_Chairperson,_Intellectual_Property_Management_cell,_Room_No.117,_Administration_Block,_Jawaharlal_Nehru_University,_New_Delhi-110067,_so_as_to_reach_this_office_on_or_before_close_of_work_on_Friday,_June_30,_2009._Interested_parties_may_also_contact: Prof._Shatendra_K_Sharma,_Director,_University_Science_ Instrumentation_Centre,_Jawaharlal_Nehru_University,_New_Delhi_110067,_India._Tel:_(011)-26742604_(0),_9810721748(M)_email: sksharma@mail.jnu.ac.in /shatendra@gmail.com

All_manufacturers_in_lighting_industry_such_as_Philips,_OSRAM,_ECE,_Bajaj,_Surya,_Sylvania_Laxman_etc.

A_novel process_and_apparatus_for_producing_metal_particles_of_various_sizes (5-20_nm),_by_electro-explosion_of_wires,_has_been_developed_by_Prof._Prasenjit_Sen,_School_of_Physical_Sciences._The_invention_comprises_detailed_processes_which_cause_a_metal_wire_to_explode_into_particles._Interested_parties_are_hereby_requested_to_submit_a_letter_of_intent_to_this_effect_and_invited_to_discuss_the_invention,_following_signing_a_non-disclosure_agreement._The_license_agreement_will_include,_amongst_others,_provisions_for_upfront_payments,_royalty_percentages_and_infringement_issues._Intent_for_the_said_technology_may_be_submitted_in_sealed_covers_to_The_Chairperson,_Intellectual_Property_Management_cell,_Room_No.117,_Administration_Block,_Jawaharlal_Nehru_University,_New_Delhi-110067,_so_as_to_reach_this_office_on_or_before_close_of_work_on_Friday,_May_15,_2009.Interested_parties_may_also_contact: Prof._Prasenjit_Sen,_School_of_Physical_Sciences,_Jawaharlal_Nehru_University,_New_Delhi_110067,_India._Tel:_(011)-26738773,_(0)9899639944_;_email: psen0700@mail.jnu.ac.in

All_manufacturing_company_which_market_the_particle_generator_in_India_only.

10.

DNA_vaccine_based_on_a_protective_antigen_of_Rabies_virus

The_technology_has_been_developed_by_Prof._Rakesh_Bhatnagar_of_School_of_Biotechnology_(SBT)._Interested_parties_who_want_to_bid_for_the_said_technology_may_submit_their_bids_by_5.00_p.m._11th_November_2008_in_the_office_of_Chairperson,_Intellectual_Property_Management_cell,_Room_No.117_Administration_Block,_Jawaharlal_Nehru_University,_New_Delhi-110067.We_have_developed_a_DNA_vaccine_based_on_a_protective_antigen_of_Rabies_virus._Here,_the_protective_antigen_was_cloned_in_a_DNA_vaccine_vector,_wherein_a_signal_sequence_is_used_to_direct_the_target_antigen_to_a_desired_location,_so_as_to_generate_maximum_immune_response._This_vaccine_has_been_tested_in_mice_and_dog_models,_wherein_it_generated_high_rabies_virus_neutralizing_antibody_titers,_which_were_64_and_16_times_respectively;_higher_than_the_minimum_adequate_titer_against_rabies_as_recommended_by_WHO._Thus,_this_DNA_vaccine_is_highly_effective_in_mice_and_dogs._Further,_this_vaccine_confers_100%_protection,_on_intracerebral_rabies_virus_challenge_in_mice._Patent_regarding_this_invention_has_already_been_filed._(We_have_already_filed_an_Indian_patent_as_well_as_PCT_to_protect_our_IPR) Interested_parties_may_also_contact: Prof._Rakesh_Bhatnagar_F.N.A.Sc.Laboratory_of_Molecular_Biology_and_Genetic_Engineering,_School_of_Biotechnology,_Jawaharlal_Nehru_University,_New_Delhi_110067,_India.Tel:_(011)-26704079,_09891446032Fax:_26742040

All_pharmaceutical_Industries

11.

The_Improved_Design_of_Battery_for_Longer_life

The_technology_has_been_developed_by_Prof._Shatendra_Sharma_of_Advanced_Instrumentation_Facility_(AIF)._Interested_parties_who_want_to_bid_for_the_said_technology_may_submit_their_bids_by_5.00_p.m._31st_December_2008_in_the_office_of_Chairperson,_Intellectual_Property_Management_cell,_Room_No.117_Administration_Block,_Jawaharlal_Nehru_University,_New_Delhi-110067. Interested_parties_may_also_contact_the_inventor: Prof._Shatendra_Sharma_Ph.D._F.I.E.,_F.I.E.T.E.,_Director,_University_Science_Instrumentation_Centre,_Jawaharlal_Nehru_University,_New_Delhi_110067,_India.Tel:_(011)-26742604,_09810721748,_Fax:_26742604

All_leading_Battery_Manufacturers_like_Exide,_Panasonic,_Okaya,_Amco,_Sanyo,_Hitachi,_Luminous _and_others

12.

An_improved_Design_of _Beverage_Packing_Can

All_large_scale_Manufacturers_like_Coke,_Pepsi,_Essel_packagings, _Fruit_juice,_milk,_Wine,_Beer_and _all_types_of_beverage_manufacturers.

13.

An_improved_design_of _Ignition_Spark_Plug_for_Internal_Combustion_Engines

All_OEM_Manufacturers_like _Mico,_Lucas_etc._and_other_automobile_component_manuafcturers